From northern Pennsylvania and New England, connect to Interstate 84, then to Route 209 South (Exit 10) through Milford or (Exit 11) Matamoras to enter the north end of the park.

From southern Pennsylvania and points west, connect to Interstate 80 East; past Stroudsburg take 209 North (Exit 52) to the middle of the park at Bushkill; or cross the I-80 bridge to first exit in New Jersey.

From New York City and New Jersey, connect to Interstate 80 West to the Delaware Water Gap at the south end of the park. Routes NJ 15 N and 206 W lead to the north end of the park and Milford, PA.

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