Everglades National Park has two entrances near Big Cypress. The Shark Valley entrance offers a visitor center and a two-hour tram tour concession through the Everglades interior. At the Gulf Coast Visitor Center, a 1.5-hour boat tour of the 10,000 Islands and canoe rentals are available. Both Everglades visitor centers offer ranger-led activities during the winter season.

A half-mile boardwalk through a cypress strand and a scenic drive are located in the nearby Fakahatchee Strand State Preserve, which shares the western border of the Big Cypress National Preserve.